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Session: ePoster: Colon and Colorectal Cancer 4 (Sun1230)

EP437 - Direct Oral Anticoagulants (DOACs) for extended deep vein thrombosis (DVT) prophylaxis post abdominal cancer surgery: protocol for a systematic review

Sunday, May 11, 2025
1:02 PM – 1:07 PM PT
Location: Monitor 5, Sails Pavilion, Upper Level

    ePoster Presenter(s)

  • Zarrukh Baig, MD MPH FRCSC

    Colorectal Surgery Fellow
    St. Paul's Hospital -Vancouver
    Vancouver, BC, Canada

    All of the relevant financial relationships listed below have been mitigated.
    This individual has no financial relationships with ineligible companies.

    • Author(s)

  • EO

    Eniola Owonifaari, BSc

    Research Assistant
    St. Paul's Hospital-Vancouver
    Vancouver, British Columbia, Canada

    Disclosure information not submitted.

  • DG

    Dean Giustini, MEd, MLS

    Biomedical Librarian
    University of British Columbia
    Vancouver, British Columbia, Canada

    Disclosure information not submitted.

  • TP

    Terry Phang, MD FRCSC

    Colorectal Surgeon
    St. Paul's Hospital-Vancouver
    Vancouver, British Columbia, Canada

    Disclosure information not submitted.

    • Senior Author(s)

  • AG

    Amandeep Ghuman, MD FRCSC

    Colorectal Surgeon
    St. Paul's Hospital-Vancouver
    Vancouver, British Columbia, Canada

    All of the relevant financial relationships listed below have been mitigated.
    This individual has no financial relationships with ineligible companies.

All of the relevant financial relationships listed below have been mitigated.
Zarrukh Baig, MD MPH FRCSC: This individual has no financial relationships with ineligible companies.
Amandeep Ghuman, MD FRCSC: This individual has no financial relationships with ineligible companies.
Image or Table (Do Not add text here):

Purpose/Background: Venous thromboembolism (VTE) is a significant postoperative complication in patients undergoing abdominal or pelvic cancer surgery, with considerable morbidity if left untreated. Extended prophylaxis using low-molecular-weight heparin (LMWH) has been the standard to prevent VTE after oncological surgery, but compliance issues and costs remain a problem. Here, the advent of Direct oral anticoagulants (DOACs) provides an alternative. Recent gynecological studies have demonstrated the efficacy of using DOACs for post-operative VTE prophylaxis as a safe alternative. This study will systematically review the evidence behind the efficacy and safety of DOACs for extended VTE prophylaxis in patients undergoing abdominal or pelvic cancer surgery.

Methods/Interventions: The search strategy was created in collaboration with a biomedical librarian. A comprehensive search was conducted using Medline (Ovid), Embase (Ovid), and the Cochrane Library from 1950 to 2024. Additional papers were located using the Web of Science Core Collection and Google Scholar, and through reference harvesting of relevant seed papers. Two independent reviewers will screen and assess studies in Covidence, resolving discrepancies with a third reviewer. Our primary outcome will be the incidence of postoperative VTE. Secondary outcomes will include major bleeding, minor bleeding, and overall survival.

Results/Outcomes: We have identified 1615 abstracts that are currently being reviewed by two independent reviewers. This protocol has been registered on the Open Science Framework (OSF) https://osf.io/qygmb/. The review will include adult patients (ages 18-65) who underwent abdominal cancer surgery. Data extraction will focus on study characteristics, intervention details, and outcomes such as VTE incidence, postoperative bleeding, and survival.

Conclusion/Discussion: This comprehensive systematic review will demonstrate the role of using DOACs as an alternative to LMWH in post-operative VTE prophylaxis after abdominal cancer surgeries.